Berberine is a bioactive compound that is commonly found in plants belonging to the genus Berberis. Throughout Asia, Berberis plants have been utilized in traditional medicine for thousands of years. It is particularly important in Ayurvedic and traditional eastern medicine [*]. 

In recent studies, berberine has demonstrated various health benefits.  It has shown potential in managing cholesterol and glucose levels [**], as well as having brain-protective properties [*]. Berberine has also been cited as an anti-viral compound [*]. 

The popularity of berberine has led to hundreds of brands flooding the marketplace; however not all supplements are created equal! Unfortunately, more than 90% of berberine supplements in the market simply DON’T WORK!

We understand the challenges in finding the right supplement for your health needs. That’s why we gathered years of research and made this guide to help you find the top-rated berberine formulas that work for you.

Berberine Benefits

  • Help lower blood sugar levels
  • Help lower cholesterol
  • Boost metabolism and digestion
  • Powerful anti-inflammatory and anti-oxidant
  • Promotes cardiovascular health

Things To Be Cautious About

Has your brand been third-party tested? You should never buy supplements that don’t have Certificate of Analysis. The studies should be conducted in labs that are not affiliated with the manufacturer. These labs verify the product for safety and potency.

Does your berberine contain cheap synthetic fillers? Some brands add artificial fillers to cut cost to offer cheap products. Some of these cheap fillers we found were titanium dioxide and artificial coloring. You should never purchase cheap products when it comes to supplements.

No return policy or customer service – A reputable supplement company will offer 100% money-back guarantee policy and provide customer support through phone number and email. We noticed many formulas out there are just copies of the top-rated brands. They don’t offer an easy refund policy or don’t even have a phone number to prove they are real.

Top 5 Berberine Supplements

The result: we reviewed over 100+ brands of Berberine Supplements in the market and complied a list of top 5 formulas based on effectiveness, safety, pricing, return policy, and overall customer satisfaction.

1. Swanson Berberine Complex

  • Shipping & Return Policy 97% 97%
  • Customer Service 96% 96%
  • Essential Ingredients 95% 95%
  • Effectiveness 97% 97%

Note: we test purchased this product. We can confirm on-time delivery, reliability and quality product from this brand.

*Individual Results May Vary – Ratings are based on Society Health Ranking System and do not necessarily reflect typical results from the use of these products. We encourage consumers to research by visiting each product websites for more information.

2. Puritan’s Pride Berberine

  • Shipping & Return Policy 97% 97%
  • Customer Service 95% 95%
  • Essential Ingredients 95% 95%
  • Effectiveness 95% 95%

Note: we test purchased this product. We can confirm on-time delivery, reliability and quality product from this brand.

*Individual Results May Vary – Ratings are based on Society Health Ranking System and do not necessarily reflect typical results from the use of these products. We encourage consumers to research by visiting each product websites for more information.

3. Now Berberine

  • Shipping & Return Policy 95% 95%
  • Customer Service 95% 95%
  • Essential Ingredients 95% 95%
  • Effectiveness 94% 94%

Note: we test purchased this product. We can confirm on-time delivery, reliability and quality product from this brand.

*Individual Results May Vary – Ratings are based on Society Health Ranking System and do not necessarily reflect typical results from the use of these products. We encourage consumers to research by visiting each product websites for more information.

4. Thorne Berberine-500

  • Shipping & Return Policy 95% 95%
  • Customer Service 96% 96%
  • Essential Ingredients 93% 93%
  • Effectiveness 93% 93%

Note: we test purchased this product. We can confirm on-time delivery, reliability and quality product from this brand.

*Individual Results May Vary – Ratings are based on Society Health Ranking System and do not necessarily reflect typical results from the use of these products. We encourage consumers to research by visiting each product websites for more information.

5. Integrative Berberine

  • Shipping & Return Policy 93% 93%
  • Customer Service 96% 96%
  • Essential Ingredients 93% 93%
  • Effectiveness 91% 91%

Note: we test purchased this product. We can confirm on-time delivery, reliability and quality product from this brand.

*Individual Results May Vary – Ratings are based on Society Health Ranking System and do not necessarily reflect typical results from the use of these products. We encourage consumers to research by visiting each product websites for more information.

Ranking Factors

Shipping & Return Policy: we check the shipping and return policy of each recommended product to make sure these brands stand behind their products.

Customer Service: we contact the top rated brands through email, chat or phone to make sure they are responsive and can answer potential questions customers might have.

Essential Ingredients: we verify the ingredients in every top rated brands, their safety and dosage amount in comparison with the latest scientific studies.

Overall Effectiveness: we check with real customers through their reviews and testimonials to make sure the top brands are as effective as they claim to be. We recommend the top 5 formulas based on their average score.

We highly recommend our reader to do their own research, read real reviews and contact any brands directly to make sure they can provide the products and services based on their needs.

1. Swanson Berberine Complex

  • Shipping & Return Policy 97% 97%
  • Customer Service 96% 96%
  • Essential Ingredients 95% 95%
  • Effectiveness 97% 97%

*This is a subjective assessment based on the strength of the available information and our independent research and customer feedback. Results may vary based on individual.

Disclosure of Material Connection: we only recommend products and services which we believe will add value to the users. However, you should assume the owner of this website and/or blog has an affiliate relationship and/or another material connection, to any suppliers of goods and services that may be discussed here and may be compensated for showing ads or recommending products or services or linking to the supplier’s website.

Sources and Citations

1. Berberine: Botanical Occurrence, Traditional Uses… https://www.frontiersin.org/articles/10.3389/fphar.2018.00557/full
2. Efficacy of berberine in … https://pubmed.ncbi.nlm.nih.gov/18442638/
3. The effects of Berberis vulgaris L. and Berberis aristata L. in… https://pubmed.ncbi.nlm.nih.gov/33040642/
4. AMPK and its Activator Berberine in the… https://pubmed.ncbi.nlm.nih.gov/32445451/
5. Antiviral activity of berberine… https://pubmed.ncbi.nlm.nih.gov/32594322/